One of the most popular and widely known characters in all of fiction, Sherlock Holmes has an enduring appeal based largely on his uncanny ability to make the most remarkable deductions from the most mundane facts. The very first words that Sherlock Holmes ever says to Dr. Watson are, "How are you? You have been in Afghanistan, I perceive." Watson responds, "How on earth did you know that?" And so a crime-solving legend is born.
In The Scientific Sherlock Holmes, James O'Brien provides an in-depth look at Holmes's use of science in his investigations. Indeed, one reason for Holmes's appeal is his frequent use of the scientific method and the vast scientific knowledge which he drew upon to solve mysteries. For instance, in heart of the book, the author reveals that Holmes was a pioneer of forensic science, making use of fingerprinting well before Scotland Yard itself had adopted the method. One of the more appealing aspects of the book is how the author includes real-world background on topics such as handwriting analysis, describing how it was used to capture the New York Zodiac killer and to clinch the case against the Lindbergh baby kidnapper.